The Neusilin

The Neusilin  is a synthetic amorphous form of Magnesium Alumino-metasilicate. It is a multifunctional excipient that can be used in both direct compression and wet granulation of solid dosage forms. Neusilin is widely used for improvement of the quality of tablets, powder, granules and capsules.

Neusilin does not develop gels with aqueous solutions unlike other Magnesium Aluminum Silicates. The different grades of Neusilin have been highly evaluated at home and abroad. It has a market presence of over 50 years in Japan.

What is Neusilin?

Neusilin® does not develop gels with aqueous solutions unlike other Magnesium Aluminum Silicates. It is available in various grades and two different pH options which makes it a versatile excipient for a wide variety of applications. With over 500 pharmaceutical preparations and a market presence of over fifty years in Japan, Neusilin® is well accepted by formulators world-wide as an aid for formulations containing antibiotics, oily actives, poorly water soluble APIs, herbal mixtures, vitamins, etc. Neusilin is also used as carrier for solid dispersions and self-micro emulsifying drug systems.

  1. Neusilin® occurs as a fine powder or as granules of Magnesium Aluminometasilicate.
  2. Neusilin® is represented by an empirical formula Al2O3·MgO·1.7SiO2·xH2O.
  3. Neusilin® is amorphous, possesses very large specific surface area and has high oil and water adsorption capacity.
  4. Neusilin® makes hard tablets at low compression forces compared to similar binders.
  5. Neusilin® increases the hardness synergy with other filler and binder excipients at low concentrations.
  6. Compounding with Neusilin® helps stabilize moisture sensitive as well as lipophilic API's.
  7. Neusilin® is stable against heat and has a long shelf life.
  8. Neusilin® is available in various grades. The grades differ in their bulk density, water content, particle size and pH.

 "Multi-problem solver"

Neusilin® is amorphous and contains either tetrahedron or octahedron of Al, Octahedron of Mg and tetrahedron of Si which are randomly attached to form a complex three dimensional structure. Neusilin® does not possess repeating units of a defined monomer.

Learn more

Experience granules of Magnesium Alumino metasilicate

General Properties of Neusilin®

Neusilin® Grades

Typical Properties :

  • BET surface area, nitrogen adsorption method
  • Japanese Industrial Standard pigment test method (JIS K5101)
  • Amount of 0.1N hydrochloric acid neutralized by 1g dried product (110°C. 7 hours)
  • Weigh 2 g of sample, add water to make 50 ml. After stirring, allow to stand for 2 minutes, Measure pH using pH meter

Package Size

  • Samples are available upon request.

Please contact us to find out your nearest Gen Store distributor.

US Pharmacopoeia National Formular

Neusilin is manufactured under strict quality control at our FDA-GMP certified facilities Neusilin® meets all the requirements of the current USP/NF and JPC. An US DMF type IV filed in 1998.

Neusilin® is safe with no reports of adverse reactions and is an accepted ingredient by the US Pharmacopoeia/National Formulary and Japanese Pharmaceutical Codex. Based on the usage as an excipient in various formulations in Japan, Neusilin® up to 1.05 g can be used for oral uptake per day.

  • Neusilin® (Alkaline grades) is also approved as antacid active ingredient where the maximum dosage is 4g / day.
  • There are no established maximum oral intake limits specified by US-FDA.
  • Encyclopedia of Pharmaceutical Additives, Japan, 2005.
  • Japanese approved list of manufacturing and import of gastrointestinal dru gs.

Neusilin® is a stable inorganic compound and meets JPC and NF specifications.

 Cosmetic

 in virtual reality. 

Unique properties of Neusilin® grade, UFL2 makes it an ideal component of cosmetic preparations. UFL2 adsorbs both oil and water up to 300% and remain flowable. It functions as an efficient carrier of volatile compounds such as fragrances and liquids giving long shelf life and lasting effect. UFL2 gives very good mattifying effect, color uniformity and is an excellent cross-linker with polyacrylate resulting in smooth and stable gel sheets.

  • Facial care products including lotions, eye shadow, cleansers, powders, facial treatment masks
  • Acne and Oily Skin treatments
  • Deodorants
  • Cosmetic Application
  • Neusilin® UFL2: Odor adsorption
  • UFL2 Application categorised

💊 Neusilin® US2 & UFL2 – 

Pharmaceutical Applications and Technical Performance

Typical Application and Dosage

The most suitable grade of Neusilin® for converting oils into free-flowing powders is Neusilin® US2.

When the oil load is high, the addition of 0.5 – 2 % Neusilin® UFL2 markedly improves flowability.

Used alone at 0.5 %, UFL2 effectively prevents sticking in oily formulations and enhances powder handling efficiency.

Oil Adsorption Capacity

Neusilin® US2 and UFL2 show superior oil adsorption capacity compared with microcrystalline cellulose (MCC) or colloidal silica, based on direct linseed oil adsorption tests.

Example: Neusilin® US2 + 30 % linseed oil, dried at 50 °C.

Both grades retain excellent powder flow and compressibility even at high oil loads.

Tablet Formulation Performance

1. Scopolia Extract & Soybean Oil Tablets

  • A mixture containing 25 % Scopolia extract or Soybean oil with 25 % Neusilin® UFL2 and equal parts lactose produced tablets with:
  • No adhesion to pestle or mortar
  • Good compressibility
  • No oil or extract exudation during storage

2. Vitamin E (Tocopherol Acetate) Tablets

  • An ethanol solution (20 – 50 %) of tocopherol acetate (VE) blended with Neusilin® US2 yields tablets containing up to 30 % Vitamin E.
  • Adding 3 % croscarmellose sodium and 1 % magnesium stearate ensures high tablet quality and stability.

Flowability and Anti-Caking Improvement

  • 0.5 % UFL2 added to potato starch significantly reduces the angle of repose, confirming improved powder flow. Electron micrographs show UFL2 particles adhering to starch surfaces, acting like “microscopic roller bearings.”
  • Adding 0.5 % UFL2 also prevents caking of hygroscopic materials such as sodium L-aspartate under 45 °C and 75 % RH for 2 days.

Tablet Hardness and Compression Efficiency

  • 10 % Neusilin® UFL2 blended with lactose produces higher hardness tablets compared to formulations with 15 % MCC.
  • Both US2 and UFL2 enable high-quality tablets at lower compression pressures, outperforming colloidal silica or calcium silicate in hardness and uniformity.

Solid Dispersion and Drug Delivery Enhancements

Neusilin® serves as an adsorbent carrier in solid dispersions for poorly water-soluble drugs, improving dissolution and bioavailability.

Key Advantages

  • High surface area and adsorption capacity
  • Excellent flow at low compression force
  • Supports higher API load
  • Inhibits recrystallization of amorphous drugs
  • Inert and thermally stable carrier

Example: BAY 12-9566 Ternary Dispersion (Gupta et al., 2001; 2002)

Hot-melt granulation using Gelucire® 50/13 and Neusilin® US2 produced free-flowing ternary dispersion granules suitable for direct tabletting, demonstrating improved dissolution and uniform particle distribution.


Self-Micro-Emulsifying Dr ug Delivery (SMEDDS)

  • Glyburide SME formulations containing Neusilin® US2 exhibited:
  • Improved flowability
  • Compact tablet structure
  • Enhanced dissolution profile compared to reference formulations (Catarzi et al., 2008)

Hygroscopic Stability

Neusilin® grades show minimal moisture uptake up to 70 % relative humidity, maintaining flowability even after absorbing up to 250 % of their own weight.

This ensures excellent storage stability under various humidity conditions.

Comfort & Ease

 Unique properties of Neusilin® grade, UFL2 makes it an ideal component of cosmetic preparations. UFL2 adsorbs both oil and water up to 300% and remain flowable. It functions as an efficient carrier of volatile compounds such as fragrances and liquids giving long shelf life and lasting effect. UFL2 gives very good mattifying effect, color uniformity and is an excellent cross-linker with polyacrylate resulting in smooth and stable gel sheets.

  • Facial care products including lotions, eye shadow, cleansers, powders, facial treatment masks.
  • Acne and Oily Skin treatments.
  • Deodorants.
  • Cosmetic Application.
  • Neusilin® UFL2: Odor adsorption
  • UFL2 Application categorised

 Pubmed publication

 Joshi et al reported the successful development of a solid microemulsion preconcentrate (NanOsorb) of Artemether (ARM), an antimalarial agent with Neusilin® as an adsorption carrier. Excipients like dibasic calcium phosphate, lactose, microcrystalline cellulose, magnesium carbonate, calcium carbonate and Aerosil® 200 did not give desired results for solidification.  NanOsorb significantly improved the therapeutic efficacy of ARM when compared to ARM solution and marketed formulation (Larither®) The acute and subacute toxicity studies successfully established the safety of the NanOsorb in animals.

Reference: Joshi M et al., Int J Pharm. 2008 Oct 1;362(1-2):172-8

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