Product Information

Typical Application and Quantity Needed in Pharmaceutical Preparations

Typical Application and Quantity Needed in Pharmaceutical Preparations

Pharmaceutical Application

I. Oils and extracts to powder

The most suitable grade for converting oil to powder is Neusilin® US2. When the oil load is comparatively high, an addition of 0.5 to 2% UFL2 will improve flowability substantially. Neusilin® UFL2 alone at 0.5% can resolve sticking issues of oily formulations.

Schematic flow

Schematic flow

Oil adsorption capacity

Oil adsorption capacity Neusilin® US2 and UFL2 grades show higher oil adsorption capacity* when compared to MCC or Colloidal silica.
*Linseed oil direct adsorption

For application data, refer to technical library.

II. Improve flow

Angle of repose after adding excipient to potato starch

Angle of repose after adding excipient to potato starch

Neusilin® UFL2 particle stick to the surface and aid flow

Potato starch (x 1,000) Potato starch
(x 1,000)
Potato starch (x 10,000) Potato starch
(x 10,000)
Potato starch + Neusilin® (x 1,000) Potato starch + Neusilin®
(x 1,000)
Potato starch + Neusilin® (x 10,000) Potato starch + Neusilin®
(x 10,000)
Electron micrograph showing Neusilin® UFL2 particles sticking to the starch surface. On addition to starch, the UFL2 particles stick to the surface and facilitate flow as in a 'roller blade' model. A 0.5% addition of UFL2 to potato starch vastly improves flowability.

III. Anti caking

Addition of 0.5% Neusilin® UFL2 prevents caking

Addition of 0.5% Neusilin® UFL2 prevents caking

Neusilin® UFL2 prevents caking at high humidity conditions

Sodium L-aspartate at 45°C, 75% RH, 2 days Sodium L-aspartate at 45°C, 75% RH, 2 days
Sodium L-aspartate with 0.5% UFL2 at 45°C, 75% RH, 2 days Sodium L-aspartate with 0.5% UFL2 at 45°C,
75% RH, 2 days

IV. Compressibility

Neusilin® UFL2 increases lactose tablet hardness

Neusilin® UFL2 increases lactose tablet hardness Compounding Lactose with 10% Neusilin® UFL2 results in higher hardness when compared to 15% microcrystalline cellulose. Neusilin® US2 at similar levels can also be used to improve hardness of tablets.

High quality tablets at low compression pressure

High quality tablets at low compression pressure Tablet hardness of cornstarch/lactose based tablets compounded with either using Neusilin® US2, colloidal silica or calcium silicate. Corn starch, lactose and excipient were mixed thoroughly. Magnesium stearate as lubricant was added prior to tabletting. Compression with Neusilin® US2 or Neusilin® UFL2 generally gives harder tablets compared to colloidal silica.

V. Solid dispersion

Formulating poorly water soluble drugs by solid dispersion leads to a remarkable improvement in dissolution and bioavailability. Neusilin® can potentially resolve problems associated with tabletting and improve efficiency of solid dispersion.

Three methods to apply adsorbent carriers in different solid dispersions

Three methods to apply adsorbent carriers in different solid dispersions

V(i). Key advantages of Neusilin® as an adsorbant

  • Improve flow
  • High quality tablets at low compression forces
  • High specific surface area
  • High adsorption capacity
  • Higher API load
  • Restricts reversion of amorphous form to crystalline state
  • Inert core material

VI. Hygroscopic velocity curve of Neusilin®

1) at 37ºC, RH 75%

37ºC, RH 75%

2) at 37ºC, RH 92%

37ºC, RH 92%

Hygroscopic equilibrium curve of Neusilin®

Hygroscopic equilibrium curve of Neusilin® The Hygroscopic velocity curve of different grades of Neusilin® indicate that Neusilin® is stable and do not absorb moisture up to 70% RH. Neusilin® remains flowable even after absorbing moisture up to 250% of its weight. Back to top