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Featured Articles

27 October 2011

Worried About the Stability of your Solid Dispersions? Incorporate Neusilin®

Solid dispersion system has shown great promise in improving the dissolution properties of poorly water-soluble drugs. Although a significant amount of knowledge has been accumulated about solid dispersion, very few commercial examples are available to rate the technology a success.
Amongst the problems, stability of amorphous solid dispersion remains one of the serious concerns to formulators. Recent publications as well as patents validate that Neusilin® keeps the drug amorphous and stable under accelerated stability conditions as well as at room temperature for up to three years. The scope of this article is to provide examples of stable solid dispersion with Neusilin® giving a very positive outlook for commercialization.


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21 September 2011

Amorphization of Pharmaceuticals by Co-grinding with Neusilin®

Amorphization of crystalline drugs can be achieved through several methods. The most common method is melting and solidifi cation by rapid cooling over liquid nitrogen or slow cooling at room temperature. Other methods for drug amorphization include milling, solvent evaporation, spray drying, and lyophilization.

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15 January 2010

Benefits of Using the Right Carrier for Solid Dispersion Systems

As early as the 1960's, the first solid dispersion technique had improved the bioavailability of poorly-water soluble drugs. Almost 50 years on and significant advances of solid dispersion knowledge, the technique still only has a few commercial examples to name.

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