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01 June 2012

Neusilin® again proves to be the most efficient adsorbent for microemulsion preconcentrate!

Joshi et al reported the successful development of a solid microemulsion preconcentrate (NanOsorb) of Artemether (ARM), an antimalarial agent with Neusilin® as an adsorption carrier. Excipients like dibasic calcium phosphate, lactose, microcrystalline cellulose, magnesium carbonate, calcium carbonate and Aerosil® 200 did not give desired results for solidification.  NanOsorb significantly improved the therapeutic efficacy of ARM when compared to ARM solution and marketed formulation (Larither®) The acute and subacute toxicity studies successfully established the safety of the NanOsorb in animals.

 

Reference: Joshi M et al., Int J Pharm. 2008 Oct 1;362(1-2):172-8.

Link to PubMed

 

 

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