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Amorphization of Pharmaceuticals by Co-grinding with Neusilin®
Amorphization of crystalline drugs can be achieved through several methods. The most common method is melting and solidifi cation by rapid cooling over liquid nitrogen or slow cooling at room temperature. Other methods for drug amorphization include milling, solvent evaporation, spray drying, and lyophilization.
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Benefits of Using the Right Carrier for Solid Dispersion Systems
As early as the 1960's, the first solid dispersion technique had improved the bioavailability of poorly-water soluble drugs. Almost 50 years on and significant advances of solid dispersion knowledge, the technique still only has a few commercial examples to name.
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